diff --git a/src/init.cpp b/src/init.cpp
index e181beab63..9e8d2ac4b7 100644
--- a/src/init.cpp
+++ b/src/init.cpp
@@ -853,12 +853,14 @@ bool AppInitParameterInteraction(const ArgsManager& args)
         nLocalServices = ServiceFlags(nLocalServices | NODE_COMPACT_FILTERS);
     }
 
-    // if using block pruning, then disallow txindex and coinstatsindex
     if (args.GetIntArg("-prune", 0)) {
         if (args.GetBoolArg("-txindex", DEFAULT_TXINDEX))
             return InitError(_("Prune mode is incompatible with -txindex."));
         if (args.GetBoolArg("-coinstatsindex", DEFAULT_COINSTATSINDEX))
             return InitError(_("Prune mode is incompatible with -coinstatsindex."));
+        if (args.GetBoolArg("-reindex-chainstate", false)) {
+            return InitError(_("Prune mode is incompatible with -reindex-chainstate. Use full -reindex instead."));
+        }
     }
 
     // If -forcednsseed is set to true, ensure -dnsseed has not been set to false
diff --git a/test/functional/feature_pruning.py b/test/functional/feature_pruning.py
index ba3c5053cb..bf19384279 100755
--- a/test/functional/feature_pruning.py
+++ b/test/functional/feature_pruning.py
@@ -141,6 +141,10 @@ class PruneTest(BitcoinTestFramework):
             expected_msg='Error: Prune mode is incompatible with -coinstatsindex.',
             extra_args=['-prune=550', '-coinstatsindex'],
         )
+        self.nodes[0].assert_start_raises_init_error(
+            expected_msg='Error: Prune mode is incompatible with -reindex-chainstate. Use full -reindex instead.',
+            extra_args=['-prune=550', '-reindex-chainstate'],
+        )
 
     def test_height_min(self):
         assert os.path.isfile(os.path.join(self.prunedir, "blk00000.dat")), "blk00000.dat is missing, pruning too early"