diff --git a/src/bitcoin-tx.cpp b/src/bitcoin-tx.cpp
index 89faa0123a5..89c03c16472 100644
--- a/src/bitcoin-tx.cpp
+++ b/src/bitcoin-tx.cpp
@@ -264,8 +264,8 @@ static void MutateTxAddInput(CMutableTransaction& tx, const std::string& strInpu
         throw std::runtime_error("TX input missing separator");
 
     // extract and validate TXID
-    uint256 txid;
-    if (!ParseHashStr(vStrInputParts[0], txid)) {
+    auto txid{Txid::FromHex(vStrInputParts[0])};
+    if (!txid) {
         throw std::runtime_error("invalid TX input txid");
     }
 
@@ -285,7 +285,7 @@ static void MutateTxAddInput(CMutableTransaction& tx, const std::string& strInpu
     }
 
     // append to transaction input list
-    CTxIn txin(Txid::FromUint256(txid), vout, CScript(), nSequenceIn);
+    CTxIn txin(*txid, vout, CScript(), nSequenceIn);
     tx.vin.push_back(txin);
 }
 
@@ -625,8 +625,8 @@ static void MutateTxSign(CMutableTransaction& tx, const std::string& flagStr)
             if (!prevOut.checkObject(types))
                 throw std::runtime_error("prevtxs internal object typecheck fail");
 
-            uint256 txid;
-            if (!ParseHashStr(prevOut["txid"].get_str(), txid)) {
+            auto txid{Txid::FromHex(prevOut["txid"].get_str())};
+            if (!txid) {
                 throw std::runtime_error("txid must be hexadecimal string (not '" + prevOut["txid"].get_str() + "')");
             }
 
@@ -634,7 +634,7 @@ static void MutateTxSign(CMutableTransaction& tx, const std::string& flagStr)
             if (nOut < 0)
                 throw std::runtime_error("vout cannot be negative");
 
-            COutPoint out(Txid::FromUint256(txid), nOut);
+            COutPoint out(*txid, nOut);
             std::vector<unsigned char> pkData(ParseHexUV(prevOut["scriptPubKey"], "scriptPubKey"));
             CScript scriptPubKey(pkData.begin(), pkData.end());
 
diff --git a/src/core_io.h b/src/core_io.h
index 4405f5c8f83..9305bb72393 100644
--- a/src/core_io.h
+++ b/src/core_io.h
@@ -37,15 +37,6 @@ std::string ScriptToAsmStr(const CScript& script, const bool fAttemptSighashDeco
 [[nodiscard]] bool DecodeHexBlk(CBlock&, const std::string& strHexBlk);
 bool DecodeHexBlockHeader(CBlockHeader&, const std::string& hex_header);
 
-/**
- * Parse a hex string into 256 bits
- * @param[in] strHex a hex-formatted, 64-character string
- * @param[out] result the result of the parsing
- * @returns true if successful, false if not
- *
- * @see ParseHashV for an RPC-oriented version of this
- */
-bool ParseHashStr(const std::string& strHex, uint256& result);
 [[nodiscard]] util::Result<int> SighashFromStr(const std::string& sighash);
 
 // core_write.cpp
diff --git a/src/core_read.cpp b/src/core_read.cpp
index 3e0485eb7bf..23f341c2304 100644
--- a/src/core_read.cpp
+++ b/src/core_read.cpp
@@ -234,15 +234,6 @@ bool DecodeHexBlk(CBlock& block, const std::string& strHexBlk)
     return true;
 }
 
-bool ParseHashStr(const std::string& strHex, uint256& result)
-{
-    if ((strHex.size() != 64) || !IsHex(strHex))
-        return false;
-
-    result.SetHexDeprecated(strHex);
-    return true;
-}
-
 util::Result<int> SighashFromStr(const std::string& sighash)
 {
     static const std::map<std::string, int> map_sighash_values = {
diff --git a/src/rest.cpp b/src/rest.cpp
index 80e6b52938d..c42bc8e40c2 100644
--- a/src/rest.cpp
+++ b/src/rest.cpp
@@ -217,9 +217,10 @@ static bool rest_headers(const std::any& context,
         return RESTERR(req, HTTP_BAD_REQUEST, strprintf("Header count is invalid or out of acceptable range (1-%u): %s", MAX_REST_HEADERS_RESULTS, raw_count));
     }
 
-    uint256 hash;
-    if (!ParseHashStr(hashStr, hash))
+    auto hash{uint256::FromHex(hashStr)};
+    if (!hash) {
         return RESTERR(req, HTTP_BAD_REQUEST, "Invalid hash: " + hashStr);
+    }
 
     const CBlockIndex* tip = nullptr;
     std::vector<const CBlockIndex*> headers;
@@ -231,7 +232,7 @@ static bool rest_headers(const std::any& context,
         LOCK(cs_main);
         CChain& active_chain = chainman.ActiveChain();
         tip = active_chain.Tip();
-        const CBlockIndex* pindex = chainman.m_blockman.LookupBlockIndex(hash);
+        const CBlockIndex* pindex{chainman.m_blockman.LookupBlockIndex(*hash)};
         while (pindex != nullptr && active_chain.Contains(pindex)) {
             headers.push_back(pindex);
             if (headers.size() == *parsed_count) {
@@ -290,9 +291,10 @@ static bool rest_block(const std::any& context,
     std::string hashStr;
     const RESTResponseFormat rf = ParseDataFormat(hashStr, strURIPart);
 
-    uint256 hash;
-    if (!ParseHashStr(hashStr, hash))
+    auto hash{uint256::FromHex(hashStr)};
+    if (!hash) {
         return RESTERR(req, HTTP_BAD_REQUEST, "Invalid hash: " + hashStr);
+    }
 
     FlatFilePos pos{};
     const CBlockIndex* pblockindex = nullptr;
@@ -303,7 +305,7 @@ static bool rest_block(const std::any& context,
     {
         LOCK(cs_main);
         tip = chainman.ActiveChain().Tip();
-        pblockindex = chainman.m_blockman.LookupBlockIndex(hash);
+        pblockindex = chainman.m_blockman.LookupBlockIndex(*hash);
         if (!pblockindex) {
             return RESTERR(req, HTTP_NOT_FOUND, hashStr + " not found");
         }
@@ -390,8 +392,8 @@ static bool rest_filter_header(const std::any& context, HTTPRequest* req, const
         return RESTERR(req, HTTP_BAD_REQUEST, strprintf("Header count is invalid or out of acceptable range (1-%u): %s", MAX_REST_HEADERS_RESULTS, raw_count));
     }
 
-    uint256 block_hash;
-    if (!ParseHashStr(raw_blockhash, block_hash)) {
+    auto block_hash{uint256::FromHex(raw_blockhash)};
+    if (!block_hash) {
         return RESTERR(req, HTTP_BAD_REQUEST, "Invalid hash: " + raw_blockhash);
     }
 
@@ -413,7 +415,7 @@ static bool rest_filter_header(const std::any& context, HTTPRequest* req, const
         ChainstateManager& chainman = *maybe_chainman;
         LOCK(cs_main);
         CChain& active_chain = chainman.ActiveChain();
-        const CBlockIndex* pindex = chainman.m_blockman.LookupBlockIndex(block_hash);
+        const CBlockIndex* pindex{chainman.m_blockman.LookupBlockIndex(*block_hash)};
         while (pindex != nullptr && active_chain.Contains(pindex)) {
             headers.push_back(pindex);
             if (headers.size() == *parsed_count)
@@ -494,8 +496,8 @@ static bool rest_block_filter(const std::any& context, HTTPRequest* req, const s
         return RESTERR(req, HTTP_BAD_REQUEST, "Invalid URI format. Expected /rest/blockfilter/<filtertype>/<blockhash>");
     }
 
-    uint256 block_hash;
-    if (!ParseHashStr(uri_parts[1], block_hash)) {
+    auto block_hash{uint256::FromHex(uri_parts[1])};
+    if (!block_hash) {
         return RESTERR(req, HTTP_BAD_REQUEST, "Invalid hash: " + uri_parts[1]);
     }
 
@@ -516,7 +518,7 @@ static bool rest_block_filter(const std::any& context, HTTPRequest* req, const s
         if (!maybe_chainman) return false;
         ChainstateManager& chainman = *maybe_chainman;
         LOCK(cs_main);
-        block_index = chainman.m_blockman.LookupBlockIndex(block_hash);
+        block_index = chainman.m_blockman.LookupBlockIndex(*block_hash);
         if (!block_index) {
             return RESTERR(req, HTTP_NOT_FOUND, uri_parts[1] + " not found");
         }
@@ -616,14 +618,14 @@ static bool rest_deploymentinfo(const std::any& context, HTTPRequest* req, const
         jsonRequest.params = UniValue(UniValue::VARR);
 
         if (!hash_str.empty()) {
-            uint256 hash;
-            if (!ParseHashStr(hash_str, hash)) {
+            auto hash{uint256::FromHex(hash_str)};
+            if (!hash) {
                 return RESTERR(req, HTTP_BAD_REQUEST, "Invalid hash: " + hash_str);
             }
 
             const ChainstateManager* chainman = GetChainman(context, req);
             if (!chainman) return false;
-            if (!WITH_LOCK(::cs_main, return chainman->m_blockman.LookupBlockIndex(ParseHashV(hash_str, "blockhash")))) {
+            if (!WITH_LOCK(::cs_main, return chainman->m_blockman.LookupBlockIndex(*hash))) {
                 return RESTERR(req, HTTP_BAD_REQUEST, "Block not found");
             }
 
@@ -704,9 +706,10 @@ static bool rest_tx(const std::any& context, HTTPRequest* req, const std::string
     std::string hashStr;
     const RESTResponseFormat rf = ParseDataFormat(hashStr, strURIPart);
 
-    uint256 hash;
-    if (!ParseHashStr(hashStr, hash))
+    auto hash{uint256::FromHex(hashStr)};
+    if (!hash) {
         return RESTERR(req, HTTP_BAD_REQUEST, "Invalid hash: " + hashStr);
+    }
 
     if (g_txindex) {
         g_txindex->BlockUntilSyncedToCurrentChain();
@@ -715,7 +718,7 @@ static bool rest_tx(const std::any& context, HTTPRequest* req, const std::string
     const NodeContext* const node = GetNodeContext(context, req);
     if (!node) return false;
     uint256 hashBlock = uint256();
-    const CTransactionRef tx = GetTransaction(/*block_index=*/nullptr, node->mempool.get(), hash, hashBlock, node->chainman->m_blockman);
+    const CTransactionRef tx{GetTransaction(/*block_index=*/nullptr, node->mempool.get(), *hash, hashBlock, node->chainman->m_blockman)};
     if (!tx) {
         return RESTERR(req, HTTP_NOT_FOUND, hashStr + " not found");
     }
diff --git a/src/rpc/mining.cpp b/src/rpc/mining.cpp
index 8482ce6eb2e..d41ec5bdc62 100644
--- a/src/rpc/mining.cpp
+++ b/src/rpc/mining.cpp
@@ -345,13 +345,11 @@ static RPCHelpMan generateblock()
     std::vector<CTransactionRef> txs;
     const auto raw_txs_or_txids = request.params[1].get_array();
     for (size_t i = 0; i < raw_txs_or_txids.size(); i++) {
-        const auto str(raw_txs_or_txids[i].get_str());
+        const auto& str{raw_txs_or_txids[i].get_str()};
 
-        uint256 hash;
         CMutableTransaction mtx;
-        if (ParseHashStr(str, hash)) {
-
-            const auto tx = mempool.get(hash);
+        if (auto hash{uint256::FromHex(str)}) {
+            const auto tx{mempool.get(*hash)};
             if (!tx) {
                 throw JSONRPCError(RPC_INVALID_ADDRESS_OR_KEY, strprintf("Transaction %s not in mempool.", str));
             }
diff --git a/src/test/blockfilter_tests.cpp b/src/test/blockfilter_tests.cpp
index b372f25ea95..470fdde30a3 100644
--- a/src/test/blockfilter_tests.cpp
+++ b/src/test/blockfilter_tests.cpp
@@ -149,8 +149,7 @@ BOOST_AUTO_TEST_CASE(blockfilters_json_test)
 
         unsigned int pos = 0;
         /*int block_height =*/ test[pos++].getInt<int>();
-        uint256 block_hash;
-        BOOST_CHECK(ParseHashStr(test[pos++].get_str(), block_hash));
+        BOOST_CHECK(uint256::FromHex(test[pos++].get_str()));
 
         CBlock block;
         BOOST_REQUIRE(DecodeHexBlk(block, test[pos++].get_str()));
@@ -165,11 +164,9 @@ BOOST_AUTO_TEST_CASE(blockfilters_json_test)
             tx_undo.vprevout.emplace_back(txout, 0, false);
         }
 
-        uint256 prev_filter_header_basic;
-        BOOST_CHECK(ParseHashStr(test[pos++].get_str(), prev_filter_header_basic));
+        uint256 prev_filter_header_basic{*Assert(uint256::FromHex(test[pos++].get_str()))};
         std::vector<unsigned char> filter_basic = ParseHex(test[pos++].get_str());
-        uint256 filter_header_basic;
-        BOOST_CHECK(ParseHashStr(test[pos++].get_str(), filter_header_basic));
+        uint256 filter_header_basic{*Assert(uint256::FromHex(test[pos++].get_str()))};
 
         BlockFilter computed_filter_basic(BlockFilterType::BASIC, block, block_undo);
         BOOST_CHECK(computed_filter_basic.GetFilter().GetEncoded() == filter_basic);
diff --git a/src/test/fuzz/hex.cpp b/src/test/fuzz/hex.cpp
index f67b820d11e..bc46863f1df 100644
--- a/src/test/fuzz/hex.cpp
+++ b/src/test/fuzz/hex.cpp
@@ -27,8 +27,7 @@ FUZZ_TARGET(hex)
         assert(ToLower(random_hex_string) == hex_data);
     }
     (void)IsHexNumber(random_hex_string);
-    uint256 result;
-    (void)ParseHashStr(random_hex_string, result);
+    (void)uint256::FromHex(random_hex_string);
     (void)uint256S(random_hex_string);
     try {
         (void)HexToPubKey(random_hex_string);