diff --git a/Cargo.lock b/Cargo.lock
index 553b3c7c99..88cc7105b8 100644
--- a/Cargo.lock
+++ b/Cargo.lock
@@ -672,7 +672,6 @@ dependencies = [
  "http",
  "import_map",
  "jsonc-parser",
- "lazy_static",
  "libc",
  "log",
  "lspower",
@@ -755,9 +754,9 @@ dependencies = [
  "anyhow",
  "futures",
  "indexmap",
- "lazy_static",
  "libc",
  "log",
+ "once_cell",
  "parking_lot",
  "pin-project",
  "serde",
@@ -778,8 +777,8 @@ dependencies = [
  "deno_core",
  "deno_web",
  "elliptic-curve",
- "lazy_static",
  "num-traits",
+ "once_cell",
  "p256",
  "p384",
  "rand 0.8.4",
@@ -934,11 +933,11 @@ dependencies = [
  "fwdansi",
  "http",
  "hyper",
- "lazy_static",
  "libc",
  "log",
  "nix",
  "notify",
+ "once_cell",
  "regex",
  "ring",
  "serde",
@@ -968,7 +967,7 @@ name = "deno_tls"
 version = "0.16.0"
 dependencies = [
  "deno_core",
- "lazy_static",
+ "once_cell",
  "rustls",
  "rustls-native-certs",
  "rustls-pemfile",
@@ -2406,9 +2405,9 @@ dependencies = [
 
 [[package]]
 name = "once_cell"
-version = "1.8.0"
+version = "1.9.0"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "692fcb63b64b1758029e0a96ee63e049ce8c5948587f2f7208df04625e5f6b56"
+checksum = "da32515d9f6e6e489d7bc9d84c71b060db7247dc035bbe44eac88cf87486d8d5"
 
 [[package]]
 name = "opaque-debug"
diff --git a/cli/Cargo.toml b/cli/Cargo.toml
index 096628ce7a..4a9e310566 100644
--- a/cli/Cargo.toml
+++ b/cli/Cargo.toml
@@ -62,13 +62,12 @@ fancy-regex = "=0.7.1"
 http = "=0.2.4"
 import_map = "=0.4.0"
 jsonc-parser = { version = "=0.17.0", features = ["serde"] }
-lazy_static = "=1.4.0"
 libc = "=0.2.106"
 log = { version = "=0.4.14", features = ["serde"] }
 lspower = "=1.4.0"
 notify = "=5.0.0-pre.12"
 num_cpus = "=1.13.0"
-once_cell = "=1.8.0"
+once_cell = "=1.9.0"
 percent-encoding = "=2.1.0"
 pin-project = "=1.0.8"
 rand = { version = "=0.8.4", features = ["small_rng"] }
diff --git a/cli/compat/mod.rs b/cli/compat/mod.rs
index 54f8b5fde9..14e168764b 100644
--- a/cli/compat/mod.rs
+++ b/cli/compat/mod.rs
@@ -7,6 +7,7 @@ use deno_core::error::AnyError;
 use deno_core::located_script_name;
 use deno_core::url::Url;
 use deno_core::JsRuntime;
+use once_cell::sync::Lazy;
 
 pub use esm_resolver::check_if_should_use_esm_loader;
 pub(crate) use esm_resolver::NodeEsmResolver;
@@ -62,15 +63,27 @@ static SUPPORTED_MODULES: &[&str] = &[
   "zlib",
 ];
 
-lazy_static::lazy_static! {
-  static ref NODE_COMPAT_URL: String = std::env::var("DENO_NODE_COMPAT_URL").map(String::into).ok()
-    .unwrap_or_else(|| STD_URL_STR.to_string());
-  static ref GLOBAL_URL_STR: String = format!("{}node/global.ts", NODE_COMPAT_URL.as_str());
-  pub(crate) static ref GLOBAL_URL: Url = Url::parse(&GLOBAL_URL_STR).unwrap();
-  static ref MODULE_URL_STR: String = format!("{}node/module.ts", NODE_COMPAT_URL.as_str());
-  pub(crate) static ref MODULE_URL: Url = Url::parse(&MODULE_URL_STR).unwrap();
-  static ref COMPAT_IMPORT_URL: Url = Url::parse("flags:compat").unwrap();
-}
+static NODE_COMPAT_URL: Lazy<String> = Lazy::new(|| {
+  std::env::var("DENO_NODE_COMPAT_URL")
+    .map(String::into)
+    .ok()
+    .unwrap_or_else(|| STD_URL_STR.to_string())
+});
+
+static GLOBAL_URL_STR: Lazy<String> =
+  Lazy::new(|| format!("{}node/global.ts", NODE_COMPAT_URL.as_str()));
+
+pub(crate) static GLOBAL_URL: Lazy<Url> =
+  Lazy::new(|| Url::parse(&GLOBAL_URL_STR).unwrap());
+
+static MODULE_URL_STR: Lazy<String> =
+  Lazy::new(|| format!("{}node/module.ts", NODE_COMPAT_URL.as_str()));
+
+pub(crate) static MODULE_URL: Lazy<Url> =
+  Lazy::new(|| Url::parse(&MODULE_URL_STR).unwrap());
+
+static COMPAT_IMPORT_URL: Lazy<Url> =
+  Lazy::new(|| Url::parse("flags:compat").unwrap());
 
 /// Provide imports into a module graph when the compat flag is true.
 pub(crate) fn get_node_imports() -> Vec<(Url, Vec<String>)> {
diff --git a/cli/diagnostics.rs b/cli/diagnostics.rs
index 0671dc500a..03255950b3 100644
--- a/cli/diagnostics.rs
+++ b/cli/diagnostics.rs
@@ -7,6 +7,7 @@ use deno_core::serde::Deserializer;
 use deno_core::serde::Serialize;
 use deno_core::serde::Serializer;
 use deno_graph::ModuleGraphError;
+use once_cell::sync::Lazy;
 use regex::Regex;
 use std::error::Error;
 use std::fmt;
@@ -65,13 +66,13 @@ const UNSTABLE_DENO_PROPS: &[&str] = &[
   "utimeSync",
 ];
 
-lazy_static::lazy_static! {
-  static ref MSG_MISSING_PROPERTY_DENO: Regex =
-    Regex::new(r#"Property '([^']+)' does not exist on type 'typeof Deno'"#)
-      .unwrap();
-  static ref MSG_SUGGESTION: Regex =
-    Regex::new(r#" Did you mean '([^']+)'\?"#).unwrap();
-}
+static MSG_MISSING_PROPERTY_DENO: Lazy<Regex> = Lazy::new(|| {
+  Regex::new(r#"Property '([^']+)' does not exist on type 'typeof Deno'"#)
+    .unwrap()
+});
+
+static MSG_SUGGESTION: Lazy<Regex> =
+  Lazy::new(|| Regex::new(r#" Did you mean '([^']+)'\?"#).unwrap());
 
 /// Potentially convert a "raw" diagnostic message from TSC to something that
 /// provides a more sensible error message given a Deno runtime context.
diff --git a/cli/flags.rs b/cli/flags.rs
index 452c2fd9a5..2cf79d44fb 100644
--- a/cli/flags.rs
+++ b/cli/flags.rs
@@ -12,6 +12,7 @@ use deno_core::url::Url;
 use deno_runtime::permissions::PermissionsOptions;
 use log::debug;
 use log::Level;
+use once_cell::sync::Lazy;
 use std::net::SocketAddr;
 use std::num::NonZeroU32;
 use std::num::NonZeroU8;
@@ -19,8 +20,8 @@ use std::num::NonZeroUsize;
 use std::path::PathBuf;
 use std::str::FromStr;
 
-lazy_static::lazy_static! {
-  static ref LONG_VERSION: String = format!(
+static LONG_VERSION: Lazy<String> = Lazy::new(|| {
+  format!(
     "{} ({}, {})\nv8 {}\ntypescript {}",
     crate::version::deno(),
     if crate::version::is_canary() {
@@ -31,8 +32,8 @@ lazy_static::lazy_static! {
     env!("TARGET"),
     deno_core::v8_version(),
     crate::version::TYPESCRIPT
-  );
-}
+  )
+});
 
 #[derive(Clone, Debug, PartialEq, Deserialize, Serialize)]
 pub struct BundleFlags {
diff --git a/cli/lsp/analysis.rs b/cli/lsp/analysis.rs
index d21abae87d..560a846031 100644
--- a/cli/lsp/analysis.rs
+++ b/cli/lsp/analysis.rs
@@ -18,52 +18,58 @@ use deno_core::ModuleSpecifier;
 use lspower::lsp;
 use lspower::lsp::Position;
 use lspower::lsp::Range;
+use once_cell::sync::Lazy;
 use regex::Regex;
 use std::cmp::Ordering;
 use std::collections::HashMap;
 
-lazy_static::lazy_static! {
-  /// Diagnostic error codes which actually are the same, and so when grouping
-  /// fixes we treat them the same.
-  static ref FIX_ALL_ERROR_CODES: HashMap<&'static str, &'static str> =
-    (&[("2339", "2339"), ("2345", "2339"),])
+/// Diagnostic error codes which actually are the same, and so when grouping
+/// fixes we treat them the same.
+static FIX_ALL_ERROR_CODES: Lazy<HashMap<&'static str, &'static str>> =
+  Lazy::new(|| {
+    (&[("2339", "2339"), ("2345", "2339")])
       .iter()
       .cloned()
-      .collect();
+      .collect()
+  });
 
-  /// Fixes which help determine if there is a preferred fix when there are
-  /// multiple fixes available.
-  static ref PREFERRED_FIXES: HashMap<&'static str, (u32, bool)> = (&[
-    ("annotateWithTypeFromJSDoc", (1, false)),
-    ("constructorForDerivedNeedSuperCall", (1, false)),
-    ("extendsInterfaceBecomesImplements", (1, false)),
-    ("awaitInSyncFunction", (1, false)),
-    ("classIncorrectlyImplementsInterface", (3, false)),
-    ("classDoesntImplementInheritedAbstractMember", (3, false)),
-    ("unreachableCode", (1, false)),
-    ("unusedIdentifier", (1, false)),
-    ("forgottenThisPropertyAccess", (1, false)),
-    ("spelling", (2, false)),
-    ("addMissingAwait", (1, false)),
-    ("fixImport", (0, true)),
-  ])
-  .iter()
-  .cloned()
-  .collect();
+/// Fixes which help determine if there is a preferred fix when there are
+/// multiple fixes available.
+static PREFERRED_FIXES: Lazy<HashMap<&'static str, (u32, bool)>> =
+  Lazy::new(|| {
+    (&[
+      ("annotateWithTypeFromJSDoc", (1, false)),
+      ("constructorForDerivedNeedSuperCall", (1, false)),
+      ("extendsInterfaceBecomesImplements", (1, false)),
+      ("awaitInSyncFunction", (1, false)),
+      ("classIncorrectlyImplementsInterface", (3, false)),
+      ("classDoesntImplementInheritedAbstractMember", (3, false)),
+      ("unreachableCode", (1, false)),
+      ("unusedIdentifier", (1, false)),
+      ("forgottenThisPropertyAccess", (1, false)),
+      ("spelling", (2, false)),
+      ("addMissingAwait", (1, false)),
+      ("fixImport", (0, true)),
+    ])
+      .iter()
+      .cloned()
+      .collect()
+  });
 
-  static ref IMPORT_SPECIFIER_RE: Regex = Regex::new(r#"\sfrom\s+["']([^"']*)["']"#).unwrap();
+static IMPORT_SPECIFIER_RE: Lazy<Regex> =
+  Lazy::new(|| Regex::new(r#"\sfrom\s+["']([^"']*)["']"#).unwrap());
 
-  static ref DENO_TYPES_RE: Regex =
-    Regex::new(r#"(?i)^\s*@deno-types\s*=\s*(?:["']([^"']+)["']|(\S+))"#)
-      .unwrap();
-  static ref TRIPLE_SLASH_REFERENCE_RE: Regex =
-    Regex::new(r"(?i)^/\s*<reference\s.*?/>").unwrap();
-  static ref PATH_REFERENCE_RE: Regex =
-    Regex::new(r#"(?i)\spath\s*=\s*["']([^"']*)["']"#).unwrap();
-  static ref TYPES_REFERENCE_RE: Regex =
-    Regex::new(r#"(?i)\stypes\s*=\s*["']([^"']*)["']"#).unwrap();
+static DENO_TYPES_RE: Lazy<Regex> = Lazy::new(|| {
+  Regex::new(r#"(?i)^\s*@deno-types\s*=\s*(?:["']([^"']+)["']|(\S+))"#).unwrap()
+});
 
-}
+static TRIPLE_SLASH_REFERENCE_RE: Lazy<Regex> =
+  Lazy::new(|| Regex::new(r"(?i)^/\s*<reference\s.*?/>").unwrap());
+
+static PATH_REFERENCE_RE: Lazy<Regex> =
+  Lazy::new(|| Regex::new(r#"(?i)\spath\s*=\s*["']([^"']*)["']"#).unwrap());
+static TYPES_REFERENCE_RE: Lazy<Regex> =
+  Lazy::new(|| Regex::new(r#"(?i)\stypes\s*=\s*["']([^"']*)["']"#).unwrap());
 
 const SUPPORTED_EXTENSIONS: &[&str] = &[".ts", ".tsx", ".js", ".jsx", ".mjs"];
 
diff --git a/cli/lsp/code_lens.rs b/cli/lsp/code_lens.rs
index 852f286abf..635f34916f 100644
--- a/cli/lsp/code_lens.rs
+++ b/cli/lsp/code_lens.rs
@@ -20,16 +20,18 @@ use deno_core::serde_json;
 use deno_core::serde_json::json;
 use deno_core::ModuleSpecifier;
 use lspower::lsp;
+use once_cell::sync::Lazy;
 use regex::Regex;
 use std::cell::RefCell;
 use std::collections::HashSet;
 use std::rc::Rc;
 use std::sync::Arc;
 
-lazy_static::lazy_static! {
-  static ref ABSTRACT_MODIFIER: Regex = Regex::new(r"\babstract\b").unwrap();
-  static ref EXPORT_MODIFIER: Regex = Regex::new(r"\bexport\b").unwrap();
-}
+static ABSTRACT_MODIFIER: Lazy<Regex> =
+  Lazy::new(|| Regex::new(r"\babstract\b").unwrap());
+
+static EXPORT_MODIFIER: Lazy<Regex> =
+  Lazy::new(|| Regex::new(r"\bexport\b").unwrap());
 
 #[derive(Debug, Deserialize, Serialize)]
 pub enum CodeLensSource {
diff --git a/cli/lsp/documents.rs b/cli/lsp/documents.rs
index 9e4a74ff20..1125d381fb 100644
--- a/cli/lsp/documents.rs
+++ b/cli/lsp/documents.rs
@@ -24,6 +24,7 @@ use deno_core::url;
 use deno_core::ModuleSpecifier;
 use deno_graph::Module;
 use lspower::lsp;
+use once_cell::sync::Lazy;
 use std::collections::BTreeMap;
 use std::collections::HashMap;
 use std::collections::HashSet;
@@ -35,20 +36,39 @@ use std::str::FromStr;
 use std::sync::Arc;
 use std::time::SystemTime;
 
-lazy_static::lazy_static! {
-  static ref JS_HEADERS: HashMap<String, String> = ([
-    ("content-type".to_string(), "application/javascript".to_string())
-  ]).iter().cloned().collect();
-  static ref JSX_HEADERS: HashMap<String, String> = ([
-    ("content-type".to_string(), "text/jsx".to_string())
-  ]).iter().cloned().collect();
-  static ref TS_HEADERS: HashMap<String, String> = ([
-    ("content-type".to_string(), "application/typescript".to_string())
-  ]).iter().cloned().collect();
-  static ref TSX_HEADERS: HashMap<String, String> = ([
-    ("content-type".to_string(), "text/tsx".to_string())
-  ]).iter().cloned().collect();
-}
+static JS_HEADERS: Lazy<HashMap<String, String>> = Lazy::new(|| {
+  ([(
+    "content-type".to_string(),
+    "application/javascript".to_string(),
+  )])
+  .iter()
+  .cloned()
+  .collect()
+});
+
+static JSX_HEADERS: Lazy<HashMap<String, String>> = Lazy::new(|| {
+  ([("content-type".to_string(), "text/jsx".to_string())])
+    .iter()
+    .cloned()
+    .collect()
+});
+
+static TS_HEADERS: Lazy<HashMap<String, String>> = Lazy::new(|| {
+  ([(
+    "content-type".to_string(),
+    "application/typescript".to_string(),
+  )])
+  .iter()
+  .cloned()
+  .collect()
+});
+
+static TSX_HEADERS: Lazy<HashMap<String, String>> = Lazy::new(|| {
+  ([("content-type".to_string(), "text/tsx".to_string())])
+    .iter()
+    .cloned()
+    .collect()
+});
 
 /// The default parser from `deno_graph` does not include the configuration
 /// options we require here, and so implementing an empty struct that provides
diff --git a/cli/lsp/path_to_regex.rs b/cli/lsp/path_to_regex.rs
index ce935ee27b..393591785f 100644
--- a/cli/lsp/path_to_regex.rs
+++ b/cli/lsp/path_to_regex.rs
@@ -29,15 +29,14 @@
 use deno_core::anyhow::anyhow;
 use deno_core::error::AnyError;
 use fancy_regex::Regex as FancyRegex;
+use once_cell::sync::Lazy;
 use regex::Regex;
 use std::collections::HashMap;
 use std::fmt;
 use std::iter::Peekable;
 
-lazy_static::lazy_static! {
-  static ref ESCAPE_STRING_RE: Regex =
-    Regex::new(r"([.+*?=^!:${}()\[\]|/\\])").unwrap();
-}
+static ESCAPE_STRING_RE: Lazy<Regex> =
+  Lazy::new(|| Regex::new(r"([.+*?=^!:${}()\[\]|/\\])").unwrap());
 
 #[derive(Debug, PartialEq, Eq)]
 enum TokenType {
diff --git a/cli/lsp/refactor.rs b/cli/lsp/refactor.rs
index 17ab4d5de1..2694b7c5af 100644
--- a/cli/lsp/refactor.rs
+++ b/cli/lsp/refactor.rs
@@ -7,6 +7,7 @@ use deno_core::serde::Deserialize;
 use deno_core::serde::Serialize;
 use deno_core::ModuleSpecifier;
 use lspower::lsp;
+use once_cell::sync::Lazy;
 
 pub struct RefactorCodeActionKind {
   pub kind: lsp::CodeActionKind,
@@ -19,58 +20,120 @@ impl RefactorCodeActionKind {
   }
 }
 
-lazy_static::lazy_static! {
-  pub static ref EXTRACT_FUNCTION: RefactorCodeActionKind = RefactorCodeActionKind {
-    kind : [lsp::CodeActionKind::REFACTOR_EXTRACT.as_str(), "function"].join(".").into(),
+pub static EXTRACT_FUNCTION: Lazy<RefactorCodeActionKind> =
+  Lazy::new(|| RefactorCodeActionKind {
+    kind: [lsp::CodeActionKind::REFACTOR_EXTRACT.as_str(), "function"]
+      .join(".")
+      .into(),
     matches_callback: Box::new(|tag: &str| tag.starts_with("function_")),
-  };
+  });
 
-  pub static ref EXTRACT_CONSTANT: RefactorCodeActionKind = RefactorCodeActionKind {
-    kind : [lsp::CodeActionKind::REFACTOR_EXTRACT.as_str(), "constant"].join(".").into(),
+pub static EXTRACT_CONSTANT: Lazy<RefactorCodeActionKind> =
+  Lazy::new(|| RefactorCodeActionKind {
+    kind: [lsp::CodeActionKind::REFACTOR_EXTRACT.as_str(), "constant"]
+      .join(".")
+      .into(),
     matches_callback: Box::new(|tag: &str| tag.starts_with("constant_")),
-  };
+  });
 
-  pub static ref EXTRACT_TYPE: RefactorCodeActionKind = RefactorCodeActionKind {
-    kind : [lsp::CodeActionKind::REFACTOR_EXTRACT.as_str(), "type"].join(".").into(),
-    matches_callback: Box::new(|tag: &str| tag.starts_with("Extract to type alias")),
-  };
+pub static EXTRACT_TYPE: Lazy<RefactorCodeActionKind> =
+  Lazy::new(|| RefactorCodeActionKind {
+    kind: [lsp::CodeActionKind::REFACTOR_EXTRACT.as_str(), "type"]
+      .join(".")
+      .into(),
+    matches_callback: Box::new(|tag: &str| {
+      tag.starts_with("Extract to type alias")
+    }),
+  });
 
-  pub static ref EXTRACT_INTERFACE: RefactorCodeActionKind = RefactorCodeActionKind {
-    kind : [lsp::CodeActionKind::REFACTOR_EXTRACT.as_str(), "interface"].join(".").into(),
-    matches_callback: Box::new(|tag: &str| tag.starts_with("Extract to interface")),
-  };
+pub static EXTRACT_INTERFACE: Lazy<RefactorCodeActionKind> =
+  Lazy::new(|| RefactorCodeActionKind {
+    kind: [lsp::CodeActionKind::REFACTOR_EXTRACT.as_str(), "interface"]
+      .join(".")
+      .into(),
+    matches_callback: Box::new(|tag: &str| {
+      tag.starts_with("Extract to interface")
+    }),
+  });
 
-  pub static ref MOVE_NEWFILE: RefactorCodeActionKind = RefactorCodeActionKind {
-    kind : [lsp::CodeActionKind::REFACTOR.as_str(), "move", "newFile"].join(".").into(),
-    matches_callback: Box::new(|tag: &str| tag.starts_with("Move to a new file")),
-  };
+pub static MOVE_NEWFILE: Lazy<RefactorCodeActionKind> =
+  Lazy::new(|| RefactorCodeActionKind {
+    kind: [lsp::CodeActionKind::REFACTOR.as_str(), "move", "newFile"]
+      .join(".")
+      .into(),
+    matches_callback: Box::new(|tag: &str| {
+      tag.starts_with("Move to a new file")
+    }),
+  });
 
-  pub static ref REWRITE_IMPORT: RefactorCodeActionKind = RefactorCodeActionKind {
-    kind : [lsp::CodeActionKind::REFACTOR_REWRITE.as_str(), "import"].join(".").into(),
-    matches_callback: Box::new(|tag: &str| tag.starts_with("Convert namespace import") || tag.starts_with("Convert named imports")),
-  };
+pub static REWRITE_IMPORT: Lazy<RefactorCodeActionKind> =
+  Lazy::new(|| RefactorCodeActionKind {
+    kind: [lsp::CodeActionKind::REFACTOR_REWRITE.as_str(), "import"]
+      .join(".")
+      .into(),
+    matches_callback: Box::new(|tag: &str| {
+      tag.starts_with("Convert namespace import")
+        || tag.starts_with("Convert named imports")
+    }),
+  });
 
-  pub static ref REWRITE_EXPORT: RefactorCodeActionKind = RefactorCodeActionKind {
-    kind : [lsp::CodeActionKind::REFACTOR_REWRITE.as_str(), "export"].join(".").into(),
-    matches_callback: Box::new(|tag: &str| tag.starts_with("Convert default export") || tag.starts_with("Convert named export")),
-  };
+pub static REWRITE_EXPORT: Lazy<RefactorCodeActionKind> =
+  Lazy::new(|| RefactorCodeActionKind {
+    kind: [lsp::CodeActionKind::REFACTOR_REWRITE.as_str(), "export"]
+      .join(".")
+      .into(),
+    matches_callback: Box::new(|tag: &str| {
+      tag.starts_with("Convert default export")
+        || tag.starts_with("Convert named export")
+    }),
+  });
 
-  pub static ref REWRITE_ARROW_BRACES: RefactorCodeActionKind = RefactorCodeActionKind {
-    kind : [lsp::CodeActionKind::REFACTOR_REWRITE.as_str(), "arrow", "braces"].join(".").into(),
-    matches_callback: Box::new(|tag: &str| tag.starts_with("Add or remove braces in an arrow function")),
-  };
+pub static REWRITE_ARROW_BRACES: Lazy<RefactorCodeActionKind> =
+  Lazy::new(|| RefactorCodeActionKind {
+    kind: [
+      lsp::CodeActionKind::REFACTOR_REWRITE.as_str(),
+      "arrow",
+      "braces",
+    ]
+    .join(".")
+    .into(),
+    matches_callback: Box::new(|tag: &str| {
+      tag.starts_with("Add or remove braces in an arrow function")
+    }),
+  });
 
-  pub static ref REWRITE_PARAMETERS_TO_DESTRUCTURED: RefactorCodeActionKind = RefactorCodeActionKind {
-    kind : [lsp::CodeActionKind::REFACTOR_REWRITE.as_str(), "parameters", "toDestructured"].join(".").into(),
-    matches_callback: Box::new(|tag: &str| tag.starts_with("Convert parameters to destructured object")),
-  };
+pub static REWRITE_PARAMETERS_TO_DESTRUCTURED: Lazy<RefactorCodeActionKind> =
+  Lazy::new(|| RefactorCodeActionKind {
+    kind: [
+      lsp::CodeActionKind::REFACTOR_REWRITE.as_str(),
+      "parameters",
+      "toDestructured",
+    ]
+    .join(".")
+    .into(),
+    matches_callback: Box::new(|tag: &str| {
+      tag.starts_with("Convert parameters to destructured object")
+    }),
+  });
 
-  pub static ref REWRITE_PROPERTY_GENERATEACCESSORS: RefactorCodeActionKind = RefactorCodeActionKind {
-    kind : [lsp::CodeActionKind::REFACTOR_REWRITE.as_str(), "property", "generateAccessors"].join(".").into(),
-    matches_callback: Box::new(|tag: &str| tag.starts_with("Generate 'get' and 'set' accessors")),
-  };
+pub static REWRITE_PROPERTY_GENERATEACCESSORS: Lazy<RefactorCodeActionKind> =
+  Lazy::new(|| RefactorCodeActionKind {
+    kind: [
+      lsp::CodeActionKind::REFACTOR_REWRITE.as_str(),
+      "property",
+      "generateAccessors",
+    ]
+    .join(".")
+    .into(),
+    matches_callback: Box::new(|tag: &str| {
+      tag.starts_with("Generate 'get' and 'set' accessors")
+    }),
+  });
 
-  pub static ref ALL_KNOWN_REFACTOR_ACTION_KINDS: Vec<&'static RefactorCodeActionKind> = vec![
+pub static ALL_KNOWN_REFACTOR_ACTION_KINDS: Lazy<
+  Vec<&'static RefactorCodeActionKind>,
+> = Lazy::new(|| {
+  vec![
     &EXTRACT_FUNCTION,
     &EXTRACT_CONSTANT,
     &EXTRACT_TYPE,
@@ -80,9 +143,9 @@ lazy_static::lazy_static! {
     &REWRITE_EXPORT,
     &REWRITE_ARROW_BRACES,
     &REWRITE_PARAMETERS_TO_DESTRUCTURED,
-    &REWRITE_PROPERTY_GENERATEACCESSORS
-  ];
-}
+    &REWRITE_PROPERTY_GENERATEACCESSORS,
+  ]
+});
 
 #[derive(Debug, Serialize, Deserialize)]
 #[serde(rename_all = "camelCase")]
diff --git a/cli/lsp/registries.rs b/cli/lsp/registries.rs
index afaefffd87..fc7e13fb7a 100644
--- a/cli/lsp/registries.rs
+++ b/cli/lsp/registries.rs
@@ -31,6 +31,7 @@ use deno_runtime::deno_web::BlobStore;
 use deno_runtime::permissions::Permissions;
 use log::error;
 use lspower::lsp;
+use once_cell::sync::Lazy;
 use regex::Regex;
 use std::collections::HashMap;
 use std::path::Path;
@@ -61,10 +62,8 @@ const COMPONENT: &percent_encoding::AsciiSet = &percent_encoding::CONTROLS
   .add(b'+')
   .add(b',');
 
-lazy_static::lazy_static! {
-  static ref REPLACEMENT_VARIABLE_RE: Regex =
-    Regex::new(r"\$\{\{?(\w+)\}?\}").unwrap();
-}
+static REPLACEMENT_VARIABLE_RE: Lazy<Regex> =
+  Lazy::new(|| Regex::new(r"\$\{\{?(\w+)\}?\}").unwrap());
 
 fn base_url(url: &Url) -> String {
   url.origin().ascii_serialization()
diff --git a/cli/lsp/tsc.rs b/cli/lsp/tsc.rs
index a0b201bc0e..d7cf470033 100644
--- a/cli/lsp/tsc.rs
+++ b/cli/lsp/tsc.rs
@@ -42,6 +42,7 @@ use log::warn;
 use lspower::jsonrpc::Error as LspError;
 use lspower::jsonrpc::Result as LspResult;
 use lspower::lsp;
+use once_cell::sync::Lazy;
 use regex::Captures;
 use regex::Regex;
 use std::borrow::Cow;
@@ -56,16 +57,23 @@ use text_size::TextSize;
 use tokio::sync::mpsc;
 use tokio::sync::oneshot;
 
-lazy_static::lazy_static! {
-  static ref BRACKET_ACCESSOR_RE: Regex = Regex::new(r#"^\[['"](.+)[\['"]\]$"#).unwrap();
-  static ref CAPTION_RE: Regex = Regex::new(r"<caption>(.*?)</caption>\s*\r?\n((?:\s|\S)*)").unwrap();
-  static ref CODEBLOCK_RE: Regex = Regex::new(r"^\s*[~`]{3}").unwrap();
-  static ref EMAIL_MATCH_RE: Regex = Regex::new(r"(.+)\s<([-.\w]+@[-.\w]+)>").unwrap();
-  static ref JSDOC_LINKS_RE: Regex = Regex::new(r"(?i)\{@(link|linkplain|linkcode) (https?://[^ |}]+?)(?:[| ]([^{}\n]+?))?\}").unwrap();
-  static ref PART_KIND_MODIFIER_RE: Regex = Regex::new(r",|\s+").unwrap();
-  static ref PART_RE: Regex = Regex::new(r"^(\S+)\s*-?\s*").unwrap();
-  static ref SCOPE_RE: Regex = Regex::new(r"scope_(\d)").unwrap();
-}
+static BRACKET_ACCESSOR_RE: Lazy<Regex> =
+  Lazy::new(|| Regex::new(r#"^\[['"](.+)[\['"]\]$"#).unwrap());
+static CAPTION_RE: Lazy<Regex> = Lazy::new(|| {
+  Regex::new(r"<caption>(.*?)</caption>\s*\r?\n((?:\s|\S)*)").unwrap()
+});
+static CODEBLOCK_RE: Lazy<Regex> =
+  Lazy::new(|| Regex::new(r"^\s*[~`]{3}").unwrap());
+static EMAIL_MATCH_RE: Lazy<Regex> =
+  Lazy::new(|| Regex::new(r"(.+)\s<([-.\w]+@[-.\w]+)>").unwrap());
+static JSDOC_LINKS_RE: Lazy<Regex> = Lazy::new(|| {
+  Regex::new(r"(?i)\{@(link|linkplain|linkcode) (https?://[^ |}]+?)(?:[| ]([^{}\n]+?))?\}").unwrap()
+});
+static PART_KIND_MODIFIER_RE: Lazy<Regex> =
+  Lazy::new(|| Regex::new(r",|\s+").unwrap());
+static PART_RE: Lazy<Regex> =
+  Lazy::new(|| Regex::new(r"^(\S+)\s*-?\s*").unwrap());
+static SCOPE_RE: Lazy<Regex> = Lazy::new(|| Regex::new(r"scope_(\d)").unwrap());
 
 const FILE_EXTENSION_KIND_MODIFIERS: &[&str] =
   &[".d.ts", ".ts", ".tsx", ".js", ".jsx", ".json"];
diff --git a/cli/lsp/urls.rs b/cli/lsp/urls.rs
index 19f53f2972..94830d34a4 100644
--- a/cli/lsp/urls.rs
+++ b/cli/lsp/urls.rs
@@ -9,13 +9,13 @@ use deno_core::error::AnyError;
 use deno_core::url::Position;
 use deno_core::url::Url;
 use deno_core::ModuleSpecifier;
+use once_cell::sync::Lazy;
 use std::collections::HashMap;
 
-lazy_static::lazy_static! {
-  /// Used in situations where a default URL needs to be used where otherwise a
-  /// panic is undesired.
-  pub(crate) static ref INVALID_SPECIFIER: ModuleSpecifier = ModuleSpecifier::parse("deno://invalid").unwrap();
-}
+/// Used in situations where a default URL needs to be used where otherwise a
+/// panic is undesired.
+pub(crate) static INVALID_SPECIFIER: Lazy<ModuleSpecifier> =
+  Lazy::new(|| ModuleSpecifier::parse("deno://invalid").unwrap());
 
 /// Matches the `encodeURIComponent()` encoding from JavaScript, which matches
 /// the component percent encoding set.
diff --git a/cli/tools/installer.rs b/cli/tools/installer.rs
index 252939f851..c32423f71e 100644
--- a/cli/tools/installer.rs
+++ b/cli/tools/installer.rs
@@ -8,6 +8,7 @@ use deno_core::error::AnyError;
 use deno_core::resolve_url_or_path;
 use deno_core::url::Url;
 use log::Level;
+use once_cell::sync::Lazy;
 use regex::Regex;
 use regex::RegexBuilder;
 use std::env;
@@ -21,15 +22,12 @@ use std::path::PathBuf;
 #[cfg(not(windows))]
 use std::os::unix::fs::PermissionsExt;
 
-lazy_static::lazy_static! {
-    static ref EXEC_NAME_RE: Regex = RegexBuilder::new(
-        r"^[a-z][\w-]*$"
-    ).case_insensitive(true).build().unwrap();
-    // Regular expression to test disk driver letter. eg "C:\\User\username\path\to"
-    static ref DRIVE_LETTER_REG: Regex = RegexBuilder::new(
-        r"^[c-z]:"
-    ).case_insensitive(true).build().unwrap();
-}
+static EXEC_NAME_RE: Lazy<Regex> = Lazy::new(|| {
+  RegexBuilder::new(r"^[a-z][\w-]*$")
+    .case_insensitive(true)
+    .build()
+    .unwrap()
+});
 
 fn validate_name(exec_name: &str) -> Result<(), AnyError> {
   if EXEC_NAME_RE.is_match(exec_name) {
@@ -375,13 +373,12 @@ fn is_in_path(dir: &Path) -> bool {
 mod tests {
   use super::*;
   use deno_core::parking_lot::Mutex;
+  use once_cell::sync::Lazy;
   use std::process::Command;
   use tempfile::TempDir;
   use test_util::testdata_path;
 
-  lazy_static::lazy_static! {
-    pub static ref ENV_LOCK: Mutex<()> = Mutex::new(());
-  }
+  pub static ENV_LOCK: Lazy<Mutex<()>> = Lazy::new(|| Mutex::new(()));
 
   #[test]
   fn install_infer_name_from_url() {
diff --git a/cli/tools/upgrade.rs b/cli/tools/upgrade.rs
index 5838cb2900..b0fddc39c0 100644
--- a/cli/tools/upgrade.rs
+++ b/cli/tools/upgrade.rs
@@ -7,6 +7,7 @@ use deno_core::error::AnyError;
 use deno_core::futures::StreamExt;
 use deno_runtime::deno_fetch::reqwest;
 use deno_runtime::deno_fetch::reqwest::Client;
+use once_cell::sync::Lazy;
 use semver_parser::version::parse as semver_parse;
 use std::fs;
 use std::io::Write;
@@ -15,9 +16,8 @@ use std::path::PathBuf;
 use std::process::Command;
 use tempfile::TempDir;
 
-lazy_static::lazy_static! {
-  static ref ARCHIVE_NAME: String = format!("deno-{}.zip", env!("TARGET"));
-}
+static ARCHIVE_NAME: Lazy<String> =
+  Lazy::new(|| format!("deno-{}.zip", env!("TARGET")));
 
 const RELEASE_URL: &str = "https://github.com/denoland/deno/releases";
 
diff --git a/cli/tsc.rs b/cli/tsc.rs
index e87cb7c7d1..b5df0c350e 100644
--- a/cli/tsc.rs
+++ b/cli/tsc.rs
@@ -25,6 +25,7 @@ use deno_core::ModuleSpecifier;
 use deno_core::OpFn;
 use deno_core::RuntimeOptions;
 use deno_core::Snapshot;
+use once_cell::sync::Lazy;
 use std::collections::HashMap;
 use std::path::PathBuf;
 use std::sync::Arc;
@@ -63,29 +64,39 @@ macro_rules! inc {
   };
 }
 
-lazy_static::lazy_static! {
-  /// Contains static assets that are not preloaded in the compiler snapshot.
-  pub(crate) static ref STATIC_ASSETS: HashMap<&'static str, &'static str> = (&[
-    ("lib.dom.asynciterable.d.ts", inc!("lib.dom.asynciterable.d.ts")),
-    ("lib.dom.d.ts", inc!("lib.dom.d.ts")),
-    ("lib.dom.iterable.d.ts", inc!("lib.dom.iterable.d.ts")),
-    ("lib.es6.d.ts", inc!("lib.es6.d.ts")),
-    ("lib.es2016.full.d.ts", inc!("lib.es2016.full.d.ts")),
-    ("lib.es2017.full.d.ts", inc!("lib.es2017.full.d.ts")),
-    ("lib.es2018.full.d.ts", inc!("lib.es2018.full.d.ts")),
-    ("lib.es2019.full.d.ts", inc!("lib.es2019.full.d.ts")),
-    ("lib.es2020.full.d.ts", inc!("lib.es2020.full.d.ts")),
-    ("lib.es2021.full.d.ts", inc!("lib.es2021.full.d.ts")),
-    ("lib.esnext.full.d.ts", inc!("lib.esnext.full.d.ts")),
-    ("lib.scripthost.d.ts", inc!("lib.scripthost.d.ts")),
-    ("lib.webworker.d.ts", inc!("lib.webworker.d.ts")),
-    ("lib.webworker.importscripts.d.ts", inc!("lib.webworker.importscripts.d.ts")),
-    ("lib.webworker.iterable.d.ts", inc!("lib.webworker.iterable.d.ts")),
-  ])
-  .iter()
-  .cloned()
-  .collect();
-}
+/// Contains static assets that are not preloaded in the compiler snapshot.
+pub(crate) static STATIC_ASSETS: Lazy<HashMap<&'static str, &'static str>> =
+  Lazy::new(|| {
+    (&[
+      (
+        "lib.dom.asynciterable.d.ts",
+        inc!("lib.dom.asynciterable.d.ts"),
+      ),
+      ("lib.dom.d.ts", inc!("lib.dom.d.ts")),
+      ("lib.dom.iterable.d.ts", inc!("lib.dom.iterable.d.ts")),
+      ("lib.es6.d.ts", inc!("lib.es6.d.ts")),
+      ("lib.es2016.full.d.ts", inc!("lib.es2016.full.d.ts")),
+      ("lib.es2017.full.d.ts", inc!("lib.es2017.full.d.ts")),
+      ("lib.es2018.full.d.ts", inc!("lib.es2018.full.d.ts")),
+      ("lib.es2019.full.d.ts", inc!("lib.es2019.full.d.ts")),
+      ("lib.es2020.full.d.ts", inc!("lib.es2020.full.d.ts")),
+      ("lib.es2021.full.d.ts", inc!("lib.es2021.full.d.ts")),
+      ("lib.esnext.full.d.ts", inc!("lib.esnext.full.d.ts")),
+      ("lib.scripthost.d.ts", inc!("lib.scripthost.d.ts")),
+      ("lib.webworker.d.ts", inc!("lib.webworker.d.ts")),
+      (
+        "lib.webworker.importscripts.d.ts",
+        inc!("lib.webworker.importscripts.d.ts"),
+      ),
+      (
+        "lib.webworker.iterable.d.ts",
+        inc!("lib.webworker.iterable.d.ts"),
+      ),
+    ])
+      .iter()
+      .cloned()
+      .collect()
+  });
 
 /// Retrieve a static asset that are included in the binary.
 pub fn get_asset(asset: &str) -> Option<&'static str> {
diff --git a/core/Cargo.toml b/core/Cargo.toml
index 584745e8f1..2bfd50b73b 100644
--- a/core/Cargo.toml
+++ b/core/Cargo.toml
@@ -16,9 +16,9 @@ path = "lib.rs"
 anyhow = "1.0.43"
 futures = "0.3.16"
 indexmap = "1.7.0"
-lazy_static = "1.4.0"
 libc = "0.2.106"
 log = "0.4.14"
+once_cell = "=1.9.0"
 parking_lot = "0.11.1"
 pin-project = "1.0.7"
 serde = { version = "1.0.129", features = ["derive"] }
diff --git a/core/bindings.rs b/core/bindings.rs
index 5f1806e4b6..8aed39ea9e 100644
--- a/core/bindings.rs
+++ b/core/bindings.rs
@@ -17,6 +17,7 @@ use crate::PromiseId;
 use crate::ZeroCopyBuf;
 use anyhow::Error;
 use log::debug;
+use once_cell::sync::Lazy;
 use serde::Deserialize;
 use serde::Serialize;
 use serde_v8::to_v8;
@@ -35,71 +36,71 @@ const UNDEFINED_OP_ID_MSG: &str =
 This error is often caused by a typo in an op name, or not calling
 JsRuntime::sync_ops_cache() after JsRuntime initialization.";
 
-lazy_static::lazy_static! {
-  pub static ref EXTERNAL_REFERENCES: v8::ExternalReferences =
+pub static EXTERNAL_REFERENCES: Lazy<v8::ExternalReferences> =
+  Lazy::new(|| {
     v8::ExternalReferences::new(&[
       v8::ExternalReference {
-        function: opcall_async.map_fn_to()
+        function: opcall_async.map_fn_to(),
       },
       v8::ExternalReference {
-        function: opcall_sync.map_fn_to()
+        function: opcall_sync.map_fn_to(),
       },
       v8::ExternalReference {
-        function: ref_op.map_fn_to()
+        function: ref_op.map_fn_to(),
       },
       v8::ExternalReference {
-        function: unref_op.map_fn_to()
+        function: unref_op.map_fn_to(),
       },
       v8::ExternalReference {
-        function: set_macrotask_callback.map_fn_to()
+        function: set_macrotask_callback.map_fn_to(),
       },
       v8::ExternalReference {
-        function: set_nexttick_callback.map_fn_to()
+        function: set_nexttick_callback.map_fn_to(),
       },
       v8::ExternalReference {
-        function: set_promise_reject_callback.map_fn_to()
+        function: set_promise_reject_callback.map_fn_to(),
       },
       v8::ExternalReference {
-        function: set_uncaught_exception_callback.map_fn_to()
+        function: set_uncaught_exception_callback.map_fn_to(),
       },
       v8::ExternalReference {
-        function: run_microtasks.map_fn_to()
+        function: run_microtasks.map_fn_to(),
       },
       v8::ExternalReference {
-        function: has_tick_scheduled.map_fn_to()
+        function: has_tick_scheduled.map_fn_to(),
       },
       v8::ExternalReference {
-        function: set_has_tick_scheduled.map_fn_to()
+        function: set_has_tick_scheduled.map_fn_to(),
       },
       v8::ExternalReference {
-        function: eval_context.map_fn_to()
+        function: eval_context.map_fn_to(),
       },
       v8::ExternalReference {
-        function: queue_microtask.map_fn_to()
+        function: queue_microtask.map_fn_to(),
       },
       v8::ExternalReference {
-        function: create_host_object.map_fn_to()
+        function: create_host_object.map_fn_to(),
       },
       v8::ExternalReference {
-        function: encode.map_fn_to()
+        function: encode.map_fn_to(),
       },
       v8::ExternalReference {
-        function: decode.map_fn_to()
+        function: decode.map_fn_to(),
       },
       v8::ExternalReference {
-        function: serialize.map_fn_to()
+        function: serialize.map_fn_to(),
       },
       v8::ExternalReference {
-        function: deserialize.map_fn_to()
+        function: deserialize.map_fn_to(),
       },
       v8::ExternalReference {
-        function: get_promise_details.map_fn_to()
+        function: get_promise_details.map_fn_to(),
       },
       v8::ExternalReference {
-        function: get_proxy_details.map_fn_to()
+        function: get_proxy_details.map_fn_to(),
       },
       v8::ExternalReference {
-        function: is_proxy.map_fn_to()
+        function: is_proxy.map_fn_to(),
       },
       v8::ExternalReference {
         function: memory_usage.map_fn_to(),
@@ -108,10 +109,10 @@ lazy_static::lazy_static! {
         function: call_console.map_fn_to(),
       },
       v8::ExternalReference {
-        function: set_wasm_streaming_callback.map_fn_to()
-      }
-    ]);
-}
+        function: set_wasm_streaming_callback.map_fn_to(),
+      },
+    ])
+  });
 
 pub fn script_origin<'a>(
   s: &mut v8::HandleScope<'a>,
diff --git a/ext/crypto/Cargo.toml b/ext/crypto/Cargo.toml
index 90cb3ceb30..67f549c4c3 100644
--- a/ext/crypto/Cargo.toml
+++ b/ext/crypto/Cargo.toml
@@ -20,8 +20,8 @@ block-modes = "0.8.1"
 deno_core = { version = "0.111.0", path = "../../core" }
 deno_web = { version = "0.60.0", path = "../web" }
 elliptic-curve = { version = "0.10.6", features = ["std", "pem"] }
-lazy_static = "1.4.0"
 num-traits = "0.2.14"
+once_cell = "=1.9.0"
 p256 = { version = "0.9.0", features = ["ecdh"] }
 p384 = "0.8.0"
 rand = "0.8.4"
diff --git a/ext/crypto/generate_key.rs b/ext/crypto/generate_key.rs
index 7ed8412973..190a8b424f 100644
--- a/ext/crypto/generate_key.rs
+++ b/ext/crypto/generate_key.rs
@@ -1,11 +1,13 @@
 use std::cell::RefCell;
 use std::rc::Rc;
 
+use crate::shared::*;
 use deno_core::error::AnyError;
 use deno_core::OpState;
 use deno_core::ZeroCopyBuf;
 use elliptic_curve::rand_core::OsRng;
 use num_traits::FromPrimitive;
+use once_cell::sync::Lazy;
 use ring::rand::SecureRandom;
 use ring::signature::EcdsaKeyPair;
 use rsa::pkcs1::ToRsaPrivateKey;
@@ -13,13 +15,11 @@ use rsa::BigUint;
 use rsa::RsaPrivateKey;
 use serde::Deserialize;
 
-use crate::shared::*;
-
 // Allowlist for RSA public exponents.
-lazy_static::lazy_static! {
-  static ref PUB_EXPONENT_1: BigUint = BigUint::from_u64(3).unwrap();
-  static ref PUB_EXPONENT_2: BigUint = BigUint::from_u64(65537).unwrap();
-}
+static PUB_EXPONENT_1: Lazy<BigUint> =
+  Lazy::new(|| BigUint::from_u64(3).unwrap());
+static PUB_EXPONENT_2: Lazy<BigUint> =
+  Lazy::new(|| BigUint::from_u64(65537).unwrap());
 
 #[derive(Deserialize)]
 #[serde(rename_all = "camelCase", tag = "algorithm")]
diff --git a/ext/crypto/lib.rs b/ext/crypto/lib.rs
index b46b27d741..1bca433ffa 100644
--- a/ext/crypto/lib.rs
+++ b/ext/crypto/lib.rs
@@ -17,8 +17,6 @@ use std::num::NonZeroU32;
 use std::rc::Rc;
 
 use block_modes::BlockMode;
-use lazy_static::lazy_static;
-use num_traits::cast::FromPrimitive;
 use p256::elliptic_curve::sec1::FromEncodedPoint;
 use p256::pkcs8::FromPrivateKey;
 use rand::rngs::OsRng;
@@ -42,7 +40,6 @@ use rsa::pkcs1::der::Encodable;
 use rsa::pkcs1::FromRsaPrivateKey;
 use rsa::pkcs1::FromRsaPublicKey;
 use rsa::pkcs8::der::asn1;
-use rsa::BigUint;
 use rsa::PublicKey;
 use rsa::RsaPrivateKey;
 use rsa::RsaPublicKey;
@@ -73,12 +70,7 @@ use crate::key::HkdfOutput;
 use crate::shared::ID_MFG1;
 use crate::shared::ID_P_SPECIFIED;
 use crate::shared::ID_SHA1_OID;
-
-// Allowlist for RSA public exponents.
-lazy_static! {
-  static ref PUB_EXPONENT_1: BigUint = BigUint::from_u64(3).unwrap();
-  static ref PUB_EXPONENT_2: BigUint = BigUint::from_u64(65537).unwrap();
-}
+use once_cell::sync::Lazy;
 
 pub fn init(maybe_seed: Option<u64>) -> Extension {
   Extension::builder()
@@ -642,53 +634,64 @@ const SALT_LENGTH_TAG: rsa::pkcs8::der::TagNumber =
 const P_SOURCE_ALGORITHM_TAG: rsa::pkcs8::der::TagNumber =
   rsa::pkcs8::der::TagNumber::new(2);
 
-lazy_static! {
-  // Default HashAlgorithm for RSASSA-PSS-params (sha1)
-  //
-  // sha1 HashAlgorithm ::= {
-  //   algorithm   id-sha1,
-  //   parameters  SHA1Parameters : NULL
-  // }
-  //
-  // SHA1Parameters ::= NULL
-  static ref SHA1_HASH_ALGORITHM: rsa::pkcs8::AlgorithmIdentifier<'static> = rsa::pkcs8::AlgorithmIdentifier {
-    // id-sha1
-    oid: ID_SHA1_OID,
-    // NULL
-    parameters: Some(asn1::Any::from(asn1::Null)),
-  };
+// Default HashAlgorithm for RSASSA-PSS-params (sha1)
+//
+// sha1 HashAlgorithm ::= {
+//   algorithm   id-sha1,
+//   parameters  SHA1Parameters : NULL
+// }
+//
+// SHA1Parameters ::= NULL
+static SHA1_HASH_ALGORITHM: Lazy<rsa::pkcs8::AlgorithmIdentifier<'static>> =
+  Lazy::new(|| {
+    rsa::pkcs8::AlgorithmIdentifier {
+      // id-sha1
+      oid: ID_SHA1_OID,
+      // NULL
+      parameters: Some(asn1::Any::from(asn1::Null)),
+    }
+  });
 
-  // TODO(@littledivy): `pkcs8` should provide AlgorithmIdentifier to Any conversion.
-  static ref ENCODED_SHA1_HASH_ALGORITHM: Vec<u8> = SHA1_HASH_ALGORITHM.to_vec().unwrap();
-  // Default MaskGenAlgrithm for RSASSA-PSS-params (mgf1SHA1)
-  //
-  // mgf1SHA1 MaskGenAlgorithm ::= {
-  //   algorithm   id-mgf1,
-  //   parameters  HashAlgorithm : sha1
-  // }
-  static ref MGF1_SHA1_MASK_ALGORITHM: rsa::pkcs8::AlgorithmIdentifier<'static> = rsa::pkcs8::AlgorithmIdentifier {
+// TODO(@littledivy): `pkcs8` should provide AlgorithmIdentifier to Any conversion.
+static ENCODED_SHA1_HASH_ALGORITHM: Lazy<Vec<u8>> =
+  Lazy::new(|| SHA1_HASH_ALGORITHM.to_vec().unwrap());
+// Default MaskGenAlgrithm for RSASSA-PSS-params (mgf1SHA1)
+//
+// mgf1SHA1 MaskGenAlgorithm ::= {
+//   algorithm   id-mgf1,
+//   parameters  HashAlgorithm : sha1
+// }
+static MGF1_SHA1_MASK_ALGORITHM: Lazy<
+  rsa::pkcs8::AlgorithmIdentifier<'static>,
+> = Lazy::new(|| {
+  rsa::pkcs8::AlgorithmIdentifier {
     // id-mgf1
     oid: ID_MFG1,
     // sha1
-    parameters: Some(asn1::Any::from_der(&ENCODED_SHA1_HASH_ALGORITHM).unwrap()),
-  };
+    parameters: Some(
+      asn1::Any::from_der(&ENCODED_SHA1_HASH_ALGORITHM).unwrap(),
+    ),
+  }
+});
 
-  // Default PSourceAlgorithm for RSAES-OAEP-params
-  // The default label is an empty string.
-  //
-  // pSpecifiedEmpty    PSourceAlgorithm ::= {
-  //   algorithm   id-pSpecified,
-  //   parameters  EncodingParameters : emptyString
-  // }
-  //
-  // emptyString    EncodingParameters ::= ''H
-  static ref P_SPECIFIED_EMPTY: rsa::pkcs8::AlgorithmIdentifier<'static> = rsa::pkcs8::AlgorithmIdentifier {
-    // id-pSpecified
-    oid: ID_P_SPECIFIED,
-    // EncodingParameters
-    parameters: Some(asn1::Any::from(asn1::OctetString::new(b"").unwrap())),
-  };
-}
+// Default PSourceAlgorithm for RSAES-OAEP-params
+// The default label is an empty string.
+//
+// pSpecifiedEmpty    PSourceAlgorithm ::= {
+//   algorithm   id-pSpecified,
+//   parameters  EncodingParameters : emptyString
+// }
+//
+// emptyString    EncodingParameters ::= ''H
+static P_SPECIFIED_EMPTY: Lazy<rsa::pkcs8::AlgorithmIdentifier<'static>> =
+  Lazy::new(|| {
+    rsa::pkcs8::AlgorithmIdentifier {
+      // id-pSpecified
+      oid: ID_P_SPECIFIED,
+      // EncodingParameters
+      parameters: Some(asn1::Any::from(asn1::OctetString::new(b"").unwrap())),
+    }
+  });
 
 impl<'a> TryFrom<rsa::pkcs8::der::asn1::Any<'a>>
   for PssPrivateKeyParameters<'a>
diff --git a/ext/tls/Cargo.toml b/ext/tls/Cargo.toml
index 2a757f62df..c3bdb5cab2 100644
--- a/ext/tls/Cargo.toml
+++ b/ext/tls/Cargo.toml
@@ -15,7 +15,7 @@ path = "lib.rs"
 
 [dependencies]
 deno_core = { version = "0.111.0", path = "../../core" }
-lazy_static = "1.4.0"
+once_cell = "=1.9.0"
 rustls = { version = "0.20", features = ["dangerous_configuration"] }
 rustls-native-certs = "0.6.1"
 rustls-pemfile = "0.2.1"
diff --git a/ext/tls/lib.rs b/ext/tls/lib.rs
index bcaf0f1be1..a6775b95d3 100644
--- a/ext/tls/lib.rs
+++ b/ext/tls/lib.rs
@@ -89,11 +89,6 @@ pub struct BasicAuth {
   pub password: String,
 }
 
-lazy_static::lazy_static! {
-  static ref CLIENT_SESSION_MEMORY_CACHE: Arc<ClientSessionMemoryCache> =
-    Arc::new(ClientSessionMemoryCache::default());
-}
-
 #[derive(Default)]
 struct ClientSessionMemoryCache(Mutex<HashMap<Vec<u8>, Vec<u8>>>);
 
diff --git a/runtime/Cargo.toml b/runtime/Cargo.toml
index d26836bd6a..33d72e706a 100644
--- a/runtime/Cargo.toml
+++ b/runtime/Cargo.toml
@@ -68,10 +68,10 @@ filetime = "0.2.15"
 fs3 = "0.5.0"
 http = "0.2.4"
 hyper = { version = "0.14.12", features = ["server", "stream", "http1", "http2", "runtime"] }
-lazy_static = "1.4.0"
 libc = "0.2.106"
 log = "0.4.14"
 notify = "=5.0.0-pre.12"
+once_cell = "=1.9.0"
 regex = "1.5.4"
 ring = "0.16.20"
 serde = { version = "1.0.129", features = ["derive"] }
diff --git a/runtime/colors.rs b/runtime/colors.rs
index 00241b4e0d..c66f528db0 100644
--- a/runtime/colors.rs
+++ b/runtime/colors.rs
@@ -1,5 +1,6 @@
 // Copyright 2018-2021 the Deno authors. All rights reserved. MIT license.
 
+use once_cell::sync::Lazy;
 use std::fmt;
 use std::io::Write;
 use termcolor::Color::{Ansi256, Black, Blue, Cyan, Green, Red, White, Yellow};
@@ -8,9 +9,8 @@ use termcolor::{Ansi, ColorSpec, WriteColor};
 #[cfg(windows)]
 use termcolor::{BufferWriter, ColorChoice};
 
-lazy_static::lazy_static! {
-  static ref NO_COLOR: bool = std::env::var_os("NO_COLOR").is_some();
-}
+static NO_COLOR: Lazy<bool> =
+  Lazy::new(|| std::env::var_os("NO_COLOR").is_some());
 
 pub fn use_color() -> bool {
   !(*NO_COLOR)
diff --git a/runtime/ops/io.rs b/runtime/ops/io.rs
index e1128e833e..89da5f508a 100644
--- a/runtime/ops/io.rs
+++ b/runtime/ops/io.rs
@@ -15,6 +15,7 @@ use deno_core::RcRef;
 use deno_core::Resource;
 use deno_core::ResourceId;
 use deno_core::ZeroCopyBuf;
+use once_cell::sync::Lazy;
 use std::borrow::Cow;
 use std::fs::File as StdFile;
 use std::io::Read;
@@ -36,32 +37,35 @@ use {
 };
 
 #[cfg(unix)]
-lazy_static::lazy_static! {
-  static ref STDIN_HANDLE: StdFile = unsafe { StdFile::from_raw_fd(0) };
-  static ref STDOUT_HANDLE: StdFile = unsafe { StdFile::from_raw_fd(1) };
-  static ref STDERR_HANDLE: StdFile = unsafe { StdFile::from_raw_fd(2) };
-}
+static STDIN_HANDLE: Lazy<StdFile> =
+  Lazy::new(|| unsafe { StdFile::from_raw_fd(0) });
+#[cfg(unix)]
+static STDOUT_HANDLE: Lazy<StdFile> =
+  Lazy::new(|| unsafe { StdFile::from_raw_fd(1) });
+#[cfg(unix)]
+static STDERR_HANDLE: Lazy<StdFile> =
+  Lazy::new(|| unsafe { StdFile::from_raw_fd(2) });
 
+/// Due to portability issues on Windows handle to stdout is created from raw
+/// file descriptor.  The caveat of that approach is fact that when this
+/// handle is dropped underlying file descriptor is closed - that is highly
+/// not desirable in case of stdout.  That's why we store this global handle
+/// that is then cloned when obtaining stdio for process. In turn when
+/// resource table is dropped storing reference to that handle, the handle
+/// itself won't be closed (so Deno.core.print) will still work.
+// TODO(ry) It should be possible to close stdout.
 #[cfg(windows)]
-lazy_static::lazy_static! {
-  /// Due to portability issues on Windows handle to stdout is created from raw
-  /// file descriptor.  The caveat of that approach is fact that when this
-  /// handle is dropped underlying file descriptor is closed - that is highly
-  /// not desirable in case of stdout.  That's why we store this global handle
-  /// that is then cloned when obtaining stdio for process. In turn when
-  /// resource table is dropped storing reference to that handle, the handle
-  /// itself won't be closed (so Deno.core.print) will still work.
-  // TODO(ry) It should be possible to close stdout.
-  static ref STDIN_HANDLE: StdFile = unsafe {
-    StdFile::from_raw_handle(GetStdHandle(winbase::STD_INPUT_HANDLE))
-  };
-  static ref STDOUT_HANDLE: StdFile = unsafe {
-    StdFile::from_raw_handle(GetStdHandle(winbase::STD_OUTPUT_HANDLE))
-  };
-  static ref STDERR_HANDLE: StdFile = unsafe {
-    StdFile::from_raw_handle(GetStdHandle(winbase::STD_ERROR_HANDLE))
-  };
-}
+static STDIN_HANDLE: Lazy<StdFile> = Lazy::new(|| unsafe {
+  StdFile::from_raw_handle(GetStdHandle(winbase::STD_INPUT_HANDLE))
+});
+#[cfg(windows)]
+static STDOUT_HANDLE: Lazy<StdFile> = Lazy::new(|| unsafe {
+  StdFile::from_raw_handle(GetStdHandle(winbase::STD_OUTPUT_HANDLE))
+});
+#[cfg(windows)]
+static STDERR_HANDLE: Lazy<StdFile> = Lazy::new(|| unsafe {
+  StdFile::from_raw_handle(GetStdHandle(winbase::STD_ERROR_HANDLE))
+});
 
 pub fn init() -> Extension {
   Extension::builder()
diff --git a/runtime/permissions.rs b/runtime/permissions.rs
index 50c126f3f3..1b0d8b914c 100644
--- a/runtime/permissions.rs
+++ b/runtime/permissions.rs
@@ -16,6 +16,7 @@ use deno_core::url;
 use deno_core::ModuleSpecifier;
 use deno_core::OpState;
 use log;
+use once_cell::sync::Lazy;
 use std::collections::HashSet;
 use std::fmt;
 use std::hash::Hash;
@@ -29,9 +30,8 @@ use std::sync::atomic::Ordering;
 
 const PERMISSION_EMOJI: &str = "⚠️";
 
-lazy_static::lazy_static! {
-  static ref DEBUG_LOG_ENABLED: bool = log::log_enabled!(log::Level::Debug);
-}
+static DEBUG_LOG_ENABLED: Lazy<bool> =
+  Lazy::new(|| log::log_enabled!(log::Level::Debug));
 
 /// Tri-state value for storing permission state
 #[derive(PartialEq, Debug, Clone, Copy, Deserialize, PartialOrd)]
@@ -2017,9 +2017,9 @@ fn permission_prompt(_message: &str) -> bool {
 static STUB_PROMPT_VALUE: AtomicBool = AtomicBool::new(true);
 
 #[cfg(test)]
-lazy_static::lazy_static! {
-  static ref PERMISSION_PROMPT_STUB_VALUE_SETTER: Mutex<PermissionPromptStubValueSetter> = Mutex::new(PermissionPromptStubValueSetter);
-}
+static PERMISSION_PROMPT_STUB_VALUE_SETTER: Lazy<
+  Mutex<PermissionPromptStubValueSetter>,
+> = Lazy::new(|| Mutex::new(PermissionPromptStubValueSetter));
 
 #[cfg(test)]
 struct PermissionPromptStubValueSetter;