diff --git a/cli/tests/testdata/npm/compare_globals/main.out b/cli/tests/testdata/npm/compare_globals/main.out
index 8b3b62bc1b..e60a39ba63 100644
--- a/cli/tests/testdata/npm/compare_globals/main.out
+++ b/cli/tests/testdata/npm/compare_globals/main.out
@@ -5,3 +5,6 @@ Download http://localhost:4545/npm/registry/@types/node/node-18.8.2.tgz
 Check file:///[WILDCARD]/npm/compare_globals/main.ts
 true
 []
+5
+undefined
+undefined
diff --git a/cli/tests/testdata/npm/compare_globals/main.ts b/cli/tests/testdata/npm/compare_globals/main.ts
index 5710d0bd59..0468404a88 100644
--- a/cli/tests/testdata/npm/compare_globals/main.ts
+++ b/cli/tests/testdata/npm/compare_globals/main.ts
@@ -12,3 +12,16 @@ type _TestHasNodeJsGlobal = NodeJS.Architecture;
 
 const controller = new AbortController();
 controller.abort("reason"); // in the NodeJS declaration it doesn't have a reason
+
+// Super edge case where some Node code deletes a global where the
+// Node code has its own global and the Deno code has the same global,
+// but it's different. Basically if some Node code deletes
+// one of these globals then we don't want it to suddenly inherit
+// the Deno global.
+globals.withNodeGlobalThis((nodeGlobalThis: any) => {
+  (globalThis as any).setTimeout = 5;
+  console.log(setTimeout);
+  delete nodeGlobalThis["setTimeout"];
+  console.log(nodeGlobalThis["setTimeout"]); // should be undefined
+  console.log(globalThis["setTimeout"]); // should be undefined
+});
diff --git a/cli/tests/testdata/npm/registry/@denotest/globals/1.0.0/index.d.ts b/cli/tests/testdata/npm/registry/@denotest/globals/1.0.0/index.d.ts
index ee03712dd4..3f3eeb92af 100644
--- a/cli/tests/testdata/npm/registry/@denotest/globals/1.0.0/index.d.ts
+++ b/cli/tests/testdata/npm/registry/@denotest/globals/1.0.0/index.d.ts
@@ -11,3 +11,5 @@ type AssertTrue<T extends true> = never;
 type _TestHasProcessGlobal = AssertTrue<
   typeof globalThis extends { process: any } ? true : false
 >;
+
+export function withNodeGlobalThis(action: (global: typeof globalThis) => void): void;
diff --git a/cli/tests/testdata/npm/registry/@denotest/globals/1.0.0/index.js b/cli/tests/testdata/npm/registry/@denotest/globals/1.0.0/index.js
index 50d2d3d2a3..daac83c664 100644
--- a/cli/tests/testdata/npm/registry/@denotest/globals/1.0.0/index.js
+++ b/cli/tests/testdata/npm/registry/@denotest/globals/1.0.0/index.js
@@ -1,3 +1,7 @@
 exports.globalThis = globalThis;
 exports.global = global;
 exports.process = process;
+
+exports.withNodeGlobalThis = function (action) {
+  action(globalThis);
+};
diff --git a/ext/node/01_node.js b/ext/node/01_node.js
index de27c5180b..bbae660834 100644
--- a/ext/node/01_node.js
+++ b/ext/node/01_node.js
@@ -12,8 +12,12 @@ const {
   ObjectDefineProperty,
   Proxy,
   ReflectDefineProperty,
+  ReflectDeleteProperty,
+  ReflectGet,
   ReflectGetOwnPropertyDescriptor,
+  ReflectHas,
   ReflectOwnKeys,
+  ReflectSet,
   Set,
   SetPrototypeHas,
 } = primordials;
@@ -27,62 +31,54 @@ function assert(cond) {
 let initialized = false;
 const nodeGlobals = {};
 const nodeGlobalThis = new Proxy(globalThis, {
-  get(_target, prop, _receiver) {
-    if (prop in nodeGlobals) {
-      return nodeGlobals[prop];
+  get(target, prop) {
+    if (ReflectHas(nodeGlobals, prop)) {
+      return ReflectGet(nodeGlobals, prop);
     } else {
-      return globalThis[prop];
+      return ReflectGet(target, prop);
     }
   },
-  set(_target, prop, value) {
-    if (prop in nodeGlobals) {
-      nodeGlobals[prop] = value;
+  set(target, prop, value) {
+    if (ReflectHas(nodeGlobals, prop)) {
+      return ReflectSet(nodeGlobals, prop, value);
     } else {
-      globalThis[prop] = value;
+      return ReflectSet(target, prop, value);
     }
-    return true;
   },
-  deleteProperty(_target, prop) {
-    let success = false;
-    if (prop in nodeGlobals) {
-      delete nodeGlobals[prop];
-      success = true;
-    }
-    if (prop in globalThis) {
-      delete globalThis[prop];
-      success = true;
-    }
-    return success;
+  has(target, prop) {
+    return ReflectHas(nodeGlobals, prop) || ReflectHas(target, prop);
   },
-  ownKeys(_target) {
-    const globalThisKeys = ReflectOwnKeys(globalThis);
+  deleteProperty(target, prop) {
+    const nodeDeleted = ReflectDeleteProperty(nodeGlobals, prop);
+    const targetDeleted = ReflectDeleteProperty(target, prop);
+    return nodeDeleted || targetDeleted;
+  },
+  ownKeys(target) {
+    const targetKeys = ReflectOwnKeys(target);
     const nodeGlobalsKeys = ReflectOwnKeys(nodeGlobals);
     const nodeGlobalsKeySet = new Set(nodeGlobalsKeys);
     return [
       ...ArrayPrototypeFilter(
-        globalThisKeys,
+        targetKeys,
         (k) => !SetPrototypeHas(nodeGlobalsKeySet, k),
       ),
       ...nodeGlobalsKeys,
     ];
   },
-  defineProperty(_target, prop, desc) {
-    if (prop in nodeGlobals) {
+  defineProperty(target, prop, desc) {
+    if (ReflectHas(nodeGlobals, prop)) {
       return ReflectDefineProperty(nodeGlobals, prop, desc);
     } else {
-      return ReflectDefineProperty(globalThis, prop, desc);
+      return ReflectDefineProperty(target, prop, desc);
     }
   },
-  getOwnPropertyDescriptor(_target, prop) {
-    if (prop in nodeGlobals) {
+  getOwnPropertyDescriptor(target, prop) {
+    if (ReflectHas(nodeGlobals, prop)) {
       return ReflectGetOwnPropertyDescriptor(nodeGlobals, prop);
     } else {
-      return ReflectGetOwnPropertyDescriptor(globalThis, prop);
+      return ReflectGetOwnPropertyDescriptor(target, prop);
     }
   },
-  has(_target, prop) {
-    return prop in nodeGlobals || prop in globalThis;
-  },
 });
 
 const nativeModuleExports = ObjectCreate(null);